diff --git a/configure b/configure
index 3b671ebaef..45a05c026e 100755
--- a/configure
+++ b/configure
@@ -2308,6 +2308,7 @@ HEADERS_LIST="
 
 INTRINSICS_LIST="
     intrinsics_neon
+    intrinsics_sse2
 "
 
 MATH_FUNCS="
@@ -2737,6 +2738,7 @@ armv6t2_deps="arm"
 armv8_deps="aarch64"
 neon_deps_any="aarch64 arm"
 intrinsics_neon_deps="neon"
+intrinsics_sse2_deps="sse2"
 vfp_deps="arm"
 vfpv3_deps="vfp"
 setend_deps="arm"
@@ -6432,6 +6434,7 @@ elif enabled loongarch; then
 fi
 
 check_cc intrinsics_neon arm_neon.h "int16x8_t test = vdupq_n_s16(0)"
+check_cc intrinsics_sse2 emmintrin.h "__m128i test = _mm_setzero_si128()"
 
 check_ldflags -Wl,--as-needed
 check_ldflags -Wl,-z,noexecstack
diff --git a/libavutil/x86/intreadwrite.h b/libavutil/x86/intreadwrite.h
index 5e57d6a8cd..9bbef00dba 100644
--- a/libavutil/x86/intreadwrite.h
+++ b/libavutil/x86/intreadwrite.h
@@ -22,6 +22,9 @@
 #define AVUTIL_X86_INTREADWRITE_H
 
 #include <stdint.h>
+#if HAVE_INTRINSICS_SSE2
+#include <emmintrin.h>
+#endif
 #include "config.h"
 #include "libavutil/attributes.h"
 
@@ -43,20 +46,16 @@ static av_always_inline void AV_COPY128(void *d, const void *s)
 
 #endif /* __SSE__ */
 
-#ifdef __SSE2__
+#if HAVE_INTRINSICS_SSE2
 
 #define AV_ZERO128 AV_ZERO128
 static av_always_inline void AV_ZERO128(void *d)
 {
-    struct v {uint64_t v[2];};
-
-    __asm__("pxor %%xmm0, %%xmm0  \n\t"
-            "movdqa   %%xmm0, %0  \n\t"
-            : "=m"(*(struct v*)d)
-            :: "xmm0");
+    __m128i zero = _mm_setzero_si128();
+    _mm_store_si128(d, zero);
 }
 
-#endif /* __SSE2__ */
+#endif /* HAVE_INTRINSICS_SSE2 */
 
 #endif /* HAVE_MMX */